DYSF — Dysferlin
DYSF belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYSF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1, LGMN +11 more | View in SCUBA |
| Fibroblasts | Smooth Muscle Differentiation Developmental | ADCY5, ASB2, CABP1, CKB, FLNC, LIMS2, PGM5, TMEM35A | View in SCUBA |
| Lymphatic endothelial | Lipid Metabolic Regulation Lipid metabolism | ANKS1A, CSGALNACT1, EFNA5, KALRN, LDB2, MLLT10, PLD1, PPARG +5 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, EIF4E3, FLOT2 +4 more | View in SCUBA |
| Pericytes | Basement Membrane Maintenance ECM production | CALCRL, EXOC3L1, FAM167B, GRB10, HSPG2, PPM1F, RAPGEF4, RFLNB +1 more | View in SCUBA |
About the gene
| Synonyms | FER1L1, LGMD2B |
|---|---|
| Chromosome | 2: 71453561-71686763 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.