SEC11C — SEC11 homolog C, signal peptidase complex subunit
SEC11C belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEC11C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome/translation Protein processing & ER | ANP32E, CDC123, EIF4E, EIF5B, EMC8, MRPL20, NME7, PDXK +9 more | View in SCUBA |
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5 +11 more | View in SCUBA |
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, HAND2, LRRC4C, MAP4K4, PYGL, SLC25A36, TBX3 +2 more | View in SCUBA |
| Goblet cells | Mucin Folding Machinery Mucus production & secretion | AGR2, KDELR2, MYDGF, OSTC, PPIB, SEC61B, SEC61G, SSR3 | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3 +21 more | View in SCUBA |
| Smooth muscle cells | BMP/TGF-beta response Activation | APBB2, GLS, ID1, ID2, IRS2, KLF10, RND3, SIPA1L2 +1 more | View in SCUBA |
About the gene
| Synonyms | SEC11L3, SPC21, SPCS4C |
|---|---|
| Chromosome | 18: 59139866-59158832 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protease |
Function
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.