ER Protein Glycosylation
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes point to ER protein processing and glycosylation: DDOST (oligosaccharyltransferase complex), ALG3 (dolichol-P-Man dependent N-glycosylation), PPIB (cyclophilin B, ER protein folding), SEC11C (ER signal peptidase), SSR4 (translocon-associated protein), PRDX4 (ER luminal peroxiredoxin), TMED3 (COPI/Golgi vesicle), CRELD2 (ER stress marker), TMEM147 (ER membrane). SNX17 (endosomal sorting), TEX264 (ER-phagy). FARSA, PTPMT1, NAXE, PPCS are metabolic outliers. MRPL3/MRPS7 are mitoribosome peripheral members. The module represents ER-associated protein glycosylation and folding.
Genes
AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3, FAM136A, FAM174C, FARSA, FKBP2, MPV17, MRPL3, MRPS7, NAXE, POLR3GL, PPCS, PPIB, PRDX4, PTPMT1, SEC11C, SNX17, SSR4, TEX264, TIGAR, TMED3, TMEM147, UROD, YIF1B
Most correlated modules
- Complex I / NADH Dehydrogenase · correlation 0.95
- Glycolytic Metabolism · correlation 0.95
- Spliceosomal snRNP · correlation 0.94
- Mitochondrial Biogenesis · correlation 0.94
- Protein Homeostasis Mixed · correlation 0.94
- RNA Processing & Repair · correlation 0.93
- Oxidative Phosphorylation · correlation 0.93
- Ribosome Biogenesis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.