Pre-mRNA Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
The top three hub genes are PPIG (cyclophilin G, interacts with SR splicing factors), SRSF10 (serine/arginine-rich splicing factor 10), and HNRNPD (heterogeneous nuclear RNP D, mRNA stability and splicing). PPIL3 is also a peptidyl-prolyl isomerase involved in splicing. KTN1 (kinectin) links to ER/ribosome tethering. SUZ12 (PRC2) and ARID1A (SWI/SNF) add chromatin regulation. EIF4E is a translation initiation factor. The dominant hub signal is pre-mRNA splicing via SR proteins and hnRNPs, with secondary chromatin/translation components. Strong coherence among top members supports this label.
Genes
AKAP7, ARID1A, CEP57, EIF4E, ENOSF1, GGNBP2, HERC5, HNRNPD, KTN1, LYRM2, NAP1L1, PPAN, PPIG, PPIL3, SRSF10, SUZ12, UNC93B1
Most correlated modules
- RNA Surveillance/NMD · correlation 0.85
- Ubiquitin-Proteasome Trafficking · correlation 0.84
- Transcriptional Repressor Complex · correlation 0.79
- Basal Lipid Metabolism · correlation 0.78
- mRNA Splicing Regulation · correlation 0.77
- Chromatin Repression · correlation 0.76
- Mitochondrial ETC · correlation 0.76
- NK Receptor Expression · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.