IGFBP6 — Insulin like growth factor binding protein 6
IGFBP6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IGFBP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CA4, CABP1, CD36, FABP5, FMNL2, ISLR, LNX1, MGLL +6 more | View in SCUBA |
| Glial cells | Neuroprotective Secretory Neroprotection | ANGPTL7, APCDD1, LRRTM1, PDLIM2, PRELP, SELENOP, TTR, TXNIP +1 more | View in SCUBA |
About the gene
| Chromosome | 12: 53097436-53102345 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor binding |
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.