Actin Cytoskeleton Dynamics
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 35 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include LCP1 (L-plastin, actin bundling in leukocytes), PAK2 (p21-activated kinase, cytoskeletal signaling), MSN (moesin, ERM family, membrane-cytoskeleton linker), ACTN4 (alpha-actinin-4, actin crosslinker), ARHGAP10 (Rho GTPase activating protein), GRB2 (adaptor for receptor signaling), STAT3 (transcription factor), SF3B2 (splicing), ILF3 (RNA binding), HP1BP3 (chromatin). LCP1, MSN, PAK2, ACTN4, and ARHGAP10 collectively point to actin cytoskeleton regulation and leukocyte motility. STAT3 and GRB2 add a signaling dimension. Some ILC1 enrichment. The module is moderate coherence with many weak members, suggesting a mixed program centered on cytoskeletal/motility regulation in NK/ILC1 cells. Neighbor context: M40 also has cytoskeletal elements; M11 is more focused on actin dynamics and leukocyte-specific motility regulators.
Genes
ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3, FIP1L1, GRB2, GTF2A2, HP1BP3, HSH2D, HSPA4, HTATSF1, ILF3, IMMT, JMJD1C, LCP1, MSN, OSBPL8, PAK2, PPM1G, RALA, SF3B2, SH3BP1, SNX10, SRSF4, STAT3, STK26, SURF4, TCF7, TMOD3, TRBC2, TXN2
Most correlated modules
- Transcription RNA Processing · correlation 0.92
- RNA Chromatin Regulation · correlation 0.91
- NK JAK3 Signaling · correlation 0.90
- Centrosome & Scaffolding · correlation 0.88
- Transcriptional Regulation · correlation 0.88
- Innate Immune Activation · correlation 0.88
- JAK-STAT Cytokine Signaling · correlation 0.88
- Antigen Processing MHC-I · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.