FERMT3 — FERM domain containing kindlin 3
FERMT3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FERMT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Adhesion Migration migration & adhesion | ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1 +11 more | View in SCUBA |
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, GTF2H5, MYL12A +11 more | |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FIP1L1 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis Housekeeping | ATP5PB, COPZ1, GPS1, HMGN4, ICAM2, LAMTOR2, LCK, LSM6 +14 more |
About the gene
| Synonyms | KIND3, MGC10966, MIG2B, UNC112C, URP2 |
|---|---|
| Chromosome | 11: 64205926-64223896 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.