RASGRP1 — RAS guanyl releasing protein 1

RASGRP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RASGRP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Ras signaling BCR/AP1/NFKb pathway	ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more	View in SCUBA
CD4⁺ T cells	Interferon Response Anti-viral	APOL6, ARL6IP5, BAX, GBP4, GBP5, IFI16, IQGAP1, IRF9 +4 more	View in SCUBA
Gamma-delta T cells	TCR-Cytokine Signaling TCR Signaling	ARHGAP26, CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19 +10 more
Mucosal-associated invariant T cell	RAS-GEF Signaling TCR Signaling	ASCC3, FBXW7, GPATCH8, HERC1, RASGRF2, TLK1, TNRC6B, TRAPPC9 +2 more

About the gene

Synonyms	CalDAG-GEFII, RASGRP
Chromosome	15: 38488103-38565575
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins
Molecular function	Guanine-nucleotide releasing factor
Biological process	Differentiation

Function

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.