FBXW7 — F-box and WD repeat domain containing 7
FBXW7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBXW7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10 +23 more | |
| Macrophages | Ubiquitin Proteasome Regulation Housekeeping | ARIH1, BTAF1, CLASP2, DENND4A, DYRK1A, FBXO11, GATAD2B, LMBR1 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | RAS-GEF Signaling TCR Signaling | ASCC3, GPATCH8, HERC1, RASGRF2, RASGRP1, TLK1, TNRC6B, TRAPPC9 +2 more | |
| Neutrophils | Ubiquitin Regulatory Signaling Housekeeping | ARID4B, CYRIB, GRB2, QKI, RAB1A, SIK3, STK10, USP9X |
About the gene
| Synonyms | AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10 |
|---|---|
| Chromosome | 4: 152320544-152536092 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Biological process | Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway |
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. Involved in bone homeostasis and negative regulation of osteoclast differentiation. Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination. Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage. The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.