SCUBA

HERC1 — HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

HERC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HERC1's module in each cell type

Cell typeModuleShares the module with
EndothelialEndocytic Membrane Remodeling
migration & adhesion		ARHGAP23, BNIP2, CDK17, EIF4G2, KCTD15, LPCAT1, LRRC8A, LUZP1 +4 moreView in SCUBA
Lymphatic endothelialChromatin Remodeling
DNA/chromatin regulation		DYRK1A, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, NCOA1, PDE8A +2 moreView in SCUBA
MacrophagesTranscriptional Regulation
Housekeeping		ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 moreView in SCUBA
Mucosal-associated invariant T cellRAS-GEF Signaling
TCR Signaling		ASCC3, FBXW7, GPATCH8, RASGRF2, RASGRP1, TLK1, TNRC6B, TRAPPC9 +2 more

About the gene

Synonymsp532, p619
Chromosome15: 63608618-63833948
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular functionGuanine-nucleotide releasing factor, Transferase
Biological processTransport, Ubl conjugation pathway

Function

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.