RAS-GEF Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
RASGRP1 is a diacylglycerol-regulated RAS GEF that is the primary activator of RAS downstream of TCR signaling in T cells; it is essential for T cell development and activation. RASGRF2 is another RAS GEF. TLK1 is a kinase that phosphorylates histones H3/H4 and Asf1 during replication-coupled chromatin assembly. FBXW7 is an SCF E3 ligase targeting MYC, JUN, NOTCH. USP47 is a deubiquitinase. HERC1 is a large HECT E3. ASCC3 is an RNA/DNA helicase in NF-κB and DNA repair. TNRC6B is GW182, central to miRNA-mediated silencing. ZFR is an RNA binding protein. TRAPPC9 activates NF-κB. The core TCR-RAS signal (RASGRP1, RASGRF2) is nested within chromatin/ubiquitin/RNA regulatory machinery. The module likely reflects post-activation gene regulatory responses.
Genes
ASCC3, FBXW7, GPATCH8, HERC1, RASGRF2, RASGRP1, TLK1, TNRC6B, TRAPPC9, USP47, ZFR
Most correlated modules
- Lymphocyte Migration · correlation 0.91
- SWI/SNF Chromatin Remodeling · correlation 0.89
- TCR Activation Signaling · correlation 0.83
- Cytoskeletal Migration · correlation 0.80
- T cell Homeostasis · correlation 0.78
- Calcineurin-NFAT Signaling · correlation 0.77
- Chromatin Remodeling · correlation 0.75
- Cellular Maintenance · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.