TNRC6B — Trinucleotide repeat containing adaptor 6B
TNRC6B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNRC6B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | AKAP9, ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3 +8 more | View in SCUBA |
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Goblet cells | Nuclear Architecture chromatin regulation & transcription | AK3, AKAP1, ATP1B1, ATRX, DSP, KDM5B, MYO6, NET1 +3 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, GAPT, LYST, MAP3K1, MNDA, POU2F2, RGS18, SLC24A4 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | RAS-GEF Signaling TCR Signaling | ASCC3, FBXW7, GPATCH8, HERC1, RASGRF2, RASGRP1, TLK1, TRAPPC9 +2 more |
About the gene
| Synonyms | KIAA1093 |
|---|---|
| Chromosome | 22: 40044817-40335808 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | RNA-mediated gene silencing, Translation regulation |
Function
Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.