T cell Transcriptional Identity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Top network hub genes include ETS1, BCL11B, and PRDM1 — three transcription factors central to T cell lineage commitment and maturation. BCL11B is an absolute requirement for T cell identity and MAIT cell development. ETS1 regulates lymphoid survival and differentiation. PRDM1/BLIMP1 drives effector T cell differentiation and terminal maturation. NRIP1 and RASSF3 contribute regulatory/signaling roles in cell fate decisions. Despite moderate coherence and several loosely associated genes (LSM14A, SPCS3, EMB), the dominant biological signal is a T cell transcriptional maturation program driven by well-established lineage-defining transcription factors.
Genes
AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2, LSM14A, LY75, NRIP1, PRDM1, PRRC2B, RASSF3, SPATA13, SPCS3, TMEM65
Most correlated modules
- PI3K-Calcineurin Signaling · correlation 0.77
- IL-12 Cytotoxic Effector · correlation 0.76
- TCR Activation Signaling · correlation 0.75
- Circadian Transcriptional Regulation · correlation 0.72
- Nuclear regulatory housekeeping · correlation 0.69
- Integrin Actin Adhesion · correlation 0.68
- IL-18 Innate Activation · correlation 0.66
- Cytoskeletal Migration · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.