AAK1 — AP2 associated kinase 1
AAK1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AAK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Stress-responsive transcription Stress | ABTB2, LPIN2, PLEC, RIGI, SKIL, TMCC3 | View in SCUBA |
| Innate lymphoid cells | Pre-mRNA Splicing RNA processing & translation | CDC42SE2, CIB1, DDX46, HNRNPM, KRT10, KTN1, LARP7, LYRM2 +3 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1, FAM133B +20 more | View in SCUBA |
| Monocytes | Autophagy Initiation Lysosomal & pahgocytosis | AGFG1, ARID3B, FHIP2A, PHC2, PTK2B, RIOK3, TMCO3, TRABD +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2, LSM14A +8 more |
About the gene
| Synonyms | DKFZp686K16132, KIAA1048 |
|---|---|
| Chromosome | 2: 69457997-69674349 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Endocytosis |
Function
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.