BTBD7 — BTB domain containing 7
BTBD7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BTBD7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | CCDC59, CWC25, DDX3Y, DNTTIP2, HNRNPU, KRR1, MRFAP1, PNRC2 +5 more | View in SCUBA |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, CD2AP, CLIP2, DAPK1, DST, ERN1, ERO1B +14 more | View in SCUBA |
About the gene
| Synonyms | FLJ10648, FUP1 |
|---|---|
| Chromosome | 14: 93237550-93333092 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
Function
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell- scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.