ATXN7 — Ataxin 7
ATXN7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATXN7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin-p53 Regulation Protein processing & ER | CCNL1, DCTN4, FNBP1, HERPUD2, MOB4, RBBP6, RNF139, TP53BP2 +4 more | |
| Macrophages | ER Stress Response Stress | ARHGEF12, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1, ERO1B +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ANKHD1, ARID1A, ARID4B, CEMIP2, CPD, CTDP1, EIF2AK3, ELF1 +5 more |
About the gene
| Synonyms | ADCAII, OPCA3, SCA7, SGF73 |
|---|---|
| Chromosome | 3: 63863155-64003462 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX- dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilization. Involved in neurodegeneration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.