RNA Chromatin Regulation
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include HNRNPU (core RNA binding protein), CWC25 (splicing factor), YTHDC1 (m6A RNA reader), SMARCA5 (chromatin remodeling helicase), KRR1 (ribosome biogenesis), WAC (chromatin/transcription), and DDX3Y (RNA helicase, Y-linked). Despite weak coherence and uniform expression, the dominant functional theme is RNA processing, splicing, and chromatin regulation. The module is weakly coherent and likely represents a mixed housekeeping RNA/chromatin program rather than a specific biological state.
Genes
BTBD7, CCDC59, CWC25, DDX3Y, DNTTIP2, HNRNPU, KRR1, MRFAP1, PNRC2, PTPN22, SMARCA5, WAC, YTHDC1, ZNF644
Most correlated modules
- Splicing & Transcription · correlation 0.93
- Transcriptional Activation · correlation 0.92
- Golgi RNA Processing · correlation 0.88
- NK Cytokine Signaling · correlation 0.88
- Integrated Stress Response · correlation 0.86
- Prostaglandin-AP1 Response · correlation 0.86
- NR4A Activation Response · correlation 0.86
- NF-κB Inflammatory Activation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.