CD2AP — CD2 associated protein
CD2AP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD2AP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2, LIFR +11 more | View in SCUBA |
| Enterocytes | Brush-border enterocyte Absorption | CEACAM20, ERBIN, GK, HHLA2, MAN1A1, MAPK6, NCKAP5, SLC36A1 | View in SCUBA |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, BTBD7, CLIP2, DAPK1, DST, ERN1, ERO1B +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | BAZ2B, C1RL, GIT2, KIF5B, MIA2, RIF1, SPAG9, SUPT16H +1 more | |
| Pericytes | RAS-Chromatin Signaling Housekeeping | CNOT6L, EFCAB14, SKAP2, SMARCA2, SOS1, TMTC1, WNK1 | View in SCUBA |
About the gene
| Synonyms | CMS |
|---|---|
| Chromosome | 6: 47477789-47627263 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Mitosis |
Function
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.