Lipid Kinase Signaling
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
A low-expression, moderately coherent mixed module with no lineage-restricted markers and uniform detection, arguing against contamination. The strongest interpretable thread is lipid/second-messenger metabolism and kinase signaling: LCLAT1 (lysocardiolipin acyltransferase, phospholipid remodeling), MGLL (monoacylglycerol lipase), DGKD (diacylglycerol kinase delta), PRKCD (DAG-activated PKC), HRAS and CACNA1H (downstream signaling/Ca2+ entry), with ARRDC4 and ABTB1 as metabolic/stress-responsive adaptors. A second sub-program of mRNA surveillance/export (SMG1, SMG7, FYTTD1, THOC-like) and chromatin/transcriptional repressors (CBX7, RUNX1T1, DNTTIP2, LMO4) is present, indicating two related basal programs rather than one tight module. Given the neighborhood (IEG stress M2, cytoskeletal scaffold M43), this looks like a basal metabolic-signaling housekeeping axis of resting SMCs rather than an activation or inflammatory response (CX3CL1 is a lone peripheral outlier).
Genes
ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DGKD, DNTTIP2, FCHSD2, FYTTD1, GLRX5, HRAS, LCLAT1, LMO4, MGLL, PRKCD, RUNX1T1, SMG1, SMG7, TRIM38
Most correlated modules
- Cytoskeletal Scaffolding · correlation 0.67
- FOXC-PRDM16 Program · correlation 0.65
- Notch-TGFbeta Signaling · correlation 0.62
- Arteriolar Mural Cells · correlation 0.61
- ER-Golgi Secretory · correlation 0.59
- KLF6/ZNF24 regulators · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.