CDKN2C — Cyclin dependent kinase inhibitor 2C
CDKN2C belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDKN2C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G1/S Entry Checkpoint Cell cycle | ARHGAP11B, ARL6IP1, BUB3, CALM2, CKS2, EMC9, MZT1, PTTG1 | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
About the gene
| Synonyms | INK4C, p18 |
|---|---|
| Chromosome | 1: 50960745-50974634 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.