G1/S Entry Checkpoint
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
PTTG1 (securin, inhibits separase until anaphase onset, APC/C substrate — canonical cell cycle gene); CDKN2C (p18-INK4c, CDK4/6 inhibitor — G1 checkpoint); CKS2 (CDK regulatory subunit, G2/M); BUB3 (spindle assembly checkpoint); MZT1 (gamma-TuRC component, centrosome/spindle assembly); ARHGAP11B (human-specific RhoGAP paralog, cortical development/cell division); ARL6IP1 (ER/endosome-associated, less clear cell cycle role); CALM2 (calmodulin-2, broadly expressed, moderate membership reflects its pleiotropic role); EMC9 (ER membrane complex, moderate membership). The module coherence is strong with CALM2 showing only moderate membership, suggesting it may be a peripheral member. The core program is G1/S checkpoint and early mitosis (PTTG1, CDKN2C, CKS2, BUB3, MZT1). Higher mean expression (0.62) and pct positive (24.4%) than the other cell cycle modules suggests this module may overlap with G1 phase cells that are more abundant than strict M-phase cells. In the context of neighboring modules, this represents the G1/S entry checkpoint arm of the proliferation neighborhood.
Genes
ARHGAP11B, ARL6IP1, BUB3, CALM2, CDKN2C, CKS2, EMC9, MZT1, PTTG1
Most correlated modules
- CDK1-Aurora Kinase Mitosis · correlation 0.95
- G2/M Cell Cycle · correlation 0.94
- Mitosis & Cytokinesis · correlation 0.94
- Mitotic Spindle · correlation 0.92
- Mitotic Kinase Cascade · correlation 0.92
- FOXM1-driven G2/M · correlation 0.92
- Mitotic Spindle · correlation 0.90
- Metabolic Housekeeping · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.