MZT1 — Mitotic spindle organizing protein 1
MZT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MZT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G1/S Entry Checkpoint Cell cycle | ARHGAP11B, ARL6IP1, BUB3, CALM2, CDKN2C, CKS2, EMC9, PTTG1 | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
About the gene
| Synonyms | C13orf37, FLJ21869, LOC440145, MGC150539, MOZART1, RP11-11C5.2 |
|---|---|
| Chromosome | 13: 72708367-72727629 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Required for the recruitment and the assembly of the gamma- tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.