CCNA2 — Cyclin A2
CCNA2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCNA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | AURKB, CDCA3, CDCA8, CDK1, KIF2C, NDC80, NUF2, NUSAP1 +3 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CDK1, CDKN3, CKS1B, KIF22, KIFC1, MAD2L1 +2 more | View in SCUBA |
| Goblet cells | Mitotic Proliferation Cell cycle | BIRC5, KIF20B, MKI67, PBK, RACGAP1, TOP2A, TPX2 | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNB1, CCNB2, CDK1, CDKN2C +14 more | View in SCUBA |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG, SGO1 +4 more | View in SCUBA |
About the gene
| Synonyms | CCN1, CCNA |
|---|---|
| Chromosome | 4: 121816444-121823883 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Cyclin |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Mitosis |
Function
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.