Mitotic Spindle
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 23 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 23 genes have a known function matching the annotation |
Why this annotation
All hub genes (TOP2A, MKI67, BIRC5, CENPF, UBE2C, TPX2, NUSAP1, CEP55, ANLN, PRC1, CCNB1/B2, AURKA, CENPE, PTTG1, ASPM, SGO2, CDKN3, HMMR) are canonical G2/M and mitotic spindle regulators. They are uniformly and massively enriched in prolif_mac (12-105x), confirming a proliferating macrophage subpopulation. Despite weak module membership scores, the biological coherence is extremely high — the weak scores reflect restriction to a rare proliferating subset rather than biological noise. This module represents the mitotic spindle/G2-M cell cycle program in proliferating gut macrophages.
Genes
ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1, CDKN2C, CDKN3, CENPE, CENPF, CEP55, HMMR, KPNA2, MKI67, NUSAP1, PRC1, PTTG1, SGO2, TOP2A, TPX2, UBE2C
Most correlated modules
- Mitotic Chromosome Condensation · correlation 0.94
- S-phase DNA Replication · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.