BIRC5 — Baculoviral IAP repeat containing 5
BIRC5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BIRC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BUB3, CENPW, CEP55, CKS1B, DTYMK +4 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, CCNA2, CDK1, CDKN3, CKS1B, KIF22, KIFC1, MAD2L1 +2 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, CENPN, CENPW, CKS1B, DTYMK, GGH, PRR11, PTTG1 +3 more | View in SCUBA |
| Goblet cells | Mitotic Proliferation Cell cycle | CCNA2, KIF20B, MKI67, PBK, RACGAP1, TOP2A, TPX2 | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | CCNB2, CDC20, CDKN3, CEP55, DLGAP5, HMMR, MKI67, TPX2 +1 more | |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, CCNA2, CCNB1, CCNB2, CDK1, CDKN2C +14 more | View in SCUBA |
| Monocytes | Mitotic Cell Cycle Cell cycle | CENPF, H1-5, H2AC14, MKI67, PCLAF, PTTG1, STMN1, TROAP | View in SCUBA |
About the gene
| Synonyms | API4, EPR-1, survivin |
|---|---|
| Chromosome | 17: 78214186-78225636 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Protease inhibitor, Repressor, Thiol protease inhibitor |
| Biological process | Apoptosis, Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis, Transcription, Transcription regulation |
Function
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.