CEACAM5 — CEA cell adhesion molecule 5
CEACAM5 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CEACAM5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | DUOX2 oxidative defense Antibacterial | CD55, DUOX2, DUOXA2, ENSG00000267881, HK2, ITGA2, TPM4 | View in SCUBA |
About the gene
| Synonyms | CD66e, CEA |
|---|---|
| Chromosome | 19: 41708585-41730433 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Apoptosis, Cell adhesion |
Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.