Senescent Surface Identity
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
Dominated by CEACAM1, CEACAM5, CEACAM7 (carcinoembryonic antigen family, highly expressed on surface-shed colonocytes and upregulated in IBD/senescence), PLAC8 (antimicrobial/senescence marker), IFI27 (interferon-stimulated gene), B2M/HLA-A/HLA-B/HLA-C (MHC class I antigen presentation), RHOC (Rho GTPase, cell polarity/migration), MISP (mitotic spindle positioning, also expressed in surface colonocytes), PLS1 (plastin, actin bundling), GCNT3 (mucin core 2 glycosylation). The CEACAM family enrichment in sen_colono (up to 9.8x) combined with MHC-I upregulation and IFI27 strongly indicates a senescent/surface-shed colonocyte identity with immune visibility. Significant UC-specific inflammation signal with remission reversal.
Genes
Most correlated modules
- Senescent Cell Death · correlation 0.94
- Junction Cytoskeletal Remodeling · correlation 0.93
- Senescent Stress Signaling · correlation 0.93
- TNF Apoptosis Resistance · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.90
- Colonocyte Cytoskeletal Contractility · correlation 0.90
- Epithelial Junction Integrity · correlation 0.90
- Senescent Colonocyte Differentiation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.