HK2 — Hexokinase 2
HK2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | DUOX2 oxidative defense Antibacterial | CD55, CEACAM5, DUOX2, DUOXA2, ENSG00000267881, ITGA2, TPM4 | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
About the gene
| Chromosome | 2: 74834127-74893359 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Kinase, Transferase |
| Biological process | Glycolysis |
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.