EFHD2 — EF-hand domain family member D2
EFHD2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EFHD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACTN4, CAPZA1, CHMP4A, CHMP5, IL12RB1, LSP1, PARP14, PIN1 +7 more | View in SCUBA |
| CD8⁺ T cells | Autophagy Metabolic Stress Stress | CREM, CTSC, DNAJB6, DOK2, GNG2, ICOS, MAP1LC3B, NDUFC1 +2 more | View in SCUBA |
| Endothelial | Hypoxia Response Stress | C1orf122, CRELD2, CSTB, FKBP1A, HIF1A, LAPTM4B, NECTIN2, RAB13 +3 more | View in SCUBA |
| Fibroblasts | ER Stress UPR Stress | ARF4, B4GALT1, BTG3, BZW1, CYCS, ELOC, LDHA, LITAF +6 more | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, FMNL1, GNAI2, GNB2 +15 more | |
| Neutrophils | Phagocytic Membrane Signaling Phagocytosis | APLP2, ATP6V1B2, CD44, CDC42EP3, CLIC1, FCER1G, FLOT1, GRINA +9 more | |
| Pericytes | NF-κB Inflammatory Activation Inflammatory | CTSS, HIF1A, IL32, LAP3, OSMR, TAPBP, TMEM165 | View in SCUBA |
About the gene
| Synonyms | MGC4342 |
|---|---|
| Chromosome | 1: 15409888-15430339 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.