DUOX2 — Dual oxidase 2
DUOX2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUOX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | DUOX2 oxidative defense Antibacterial | CD55, CEACAM5, DUOXA2, ENSG00000267881, HK2, ITGA2, TPM4 | View in SCUBA |
| Goblet cells | DUOX2 Epithelial Inflammation Stress | AKAP13, BIRC3, DUOXA2, DUSP4, IL2RG, IL32, ISG15, RNF213 +1 more | View in SCUBA |
About the gene
| Synonyms | LNOX2, P138-TOX, P138(TOX), THOX2 |
|---|---|
| Chromosome | 15: 45092650-45114172 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Oxidoreductase, Peroxidase |
| Biological process | Hydrogen peroxide, Thyroid hormones biosynthesis |
Function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.