S-phase Replication
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes point to S-phase DNA replication and DNA repair programs. E2F7 and E2F8 are atypical E2F repressors that restrain G1/S gene expression and are themselves S-phase targets; POLQ (Pol theta) mediates microhomology-mediated end joining and is upregulated in S/G2; ESCO2 establishes sister-chromatid cohesion during replication; NCAPD3 is a condensin II subunit required for chromosome compaction; FAM111A is a replication fork protector; STIL is a centriole duplication gene induced in S phase; CEP152 is a centrosome duplication factor; ATAD2 is a chromatin regulator promoting S-phase transcription. All genes are core members with uniform low pct positive (~4.1%), consistent with replicating CD8 T cells. As a neighbor to M29 and M58, this module captures the S-phase/DNA replication arm of the cell cycle, complementing the G2/M programs in the batch.
Genes
ATAD2, CEP152, E2F7, E2F8, ESCO2, FAM111A, NCAPD3, POLQ, STIL
Most correlated modules
- Spindle Bipolarity Cytokinesis · correlation 0.93
- Mitotic Spindle Assembly · correlation 0.92
- FOXM1-driven G2/M · correlation 0.90
- S-phase Chromatin Replication · correlation 0.89
- G2/M Checkpoint · correlation 0.86
- Replication Stress Checkpoint · correlation 0.86
- Mitosis & Cytokinesis · correlation 0.86
- Epigenetic Chromatin Maintenance · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.