CIT — Citron rho-interacting serine/threonine kinase
CIT belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CIT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Spindle Bipolarity Cytokinesis Cell cycle | ANLN, ARHGAP11A, BUB1B, C21orf58, DIAPH3, ECT2, KIF11, KIF15 +4 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, AKAP12, COL27A1, ITGB4, LGI4, NRP2, SAMHD1, SYT10 | View in SCUBA |
About the gene
| Synonyms | CITK, CRIK, KIAA0949, STK21 |
|---|---|
| Chromosome | 12: 119685791-119877320 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis |
Function
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.