LGI4 — Leucine rich repeat LGI family member 4
LGI4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LGI4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC niche interactaion Gut motility | ABCC9, ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX +10 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, AKAP12, CIT, COL27A1, ITGB4, NRP2, SAMHD1, SYT10 | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LMOD1, MAP1LC3A, NFASC +11 more | View in SCUBA |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, EBF1, FRMD4A, FRY, ITGA7, LGALSL, MCAM, MEF2C +6 more | View in SCUBA |
About the gene
| Chromosome | 19: 35124513-35142451 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
Function
Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.