Spindle Bipolarity Cytokinesis
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
KIF15 and KIF11 are bipolar kinesins essential for spindle bipolarity; ANLN (anillin, cytokinesis contractile ring); ECT2 (RhoGEF, cytokinesis); KIF4A (chromokinesin, chromosome positioning and cytokinesis); C21orf58 (spindle-associated); ARHGAP11A (RhoGAP, cytokinesis/cortical organization); BUB1B (BubR1, spindle assembly checkpoint kinase); CIT (citron kinase, cytokinesis); NCAPH (condensin I subunit, chromosome condensation/segregation); KIF18B (kinesin, microtubule dynamics); DIAPH3 (diaphanous formin, actin polymerization during cytokinesis); PLK4 (polo-like kinase 4, centriole duplication). This module emphasizes kinesin-mediated spindle bipolarity and actomyosin-driven cytokinesis, and is distinguishable from M77 by the preponderance of kinesin motors and cytokinetic actin regulators (ANLN, ECT2, CIT, DIAPH3). Very low pct positive (2.4%) reflects rare dividing cells.
Genes
ANLN, ARHGAP11A, BUB1B, C21orf58, CIT, DIAPH3, ECT2, KIF11, KIF15, KIF18B, KIF4A, NCAPH, PLK4
Most correlated modules
- FOXM1-driven G2/M · correlation 0.97
- Mitosis & Cytokinesis · correlation 0.96
- Mitotic Spindle · correlation 0.95
- S-phase Chromatin Replication · correlation 0.95
- G2/M Cell Cycle · correlation 0.93
- Mitotic Spindle Assembly · correlation 0.93
- S-phase Replication · correlation 0.93
- CDK1-Aurora Kinase Mitosis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.