ITGB4 — Integrin subunit beta 4
ITGB4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGB4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, JAM2, LIFR +11 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, AKAP12, CIT, COL27A1, LGI4, NRP2, SAMHD1, SYT10 | View in SCUBA |
| Pericytes | Vascular Barrier Integrity Migration & adhesion | C1orf115, FAM107A, GIMAP1, GIMAP4, GIMAP7, JAM2, MYCT1, NRN1 +2 more | View in SCUBA |
About the gene
| Synonyms | CD104 |
|---|---|
| Chromosome | 17: 75721328-75757818 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.