SYT10 — Synaptotagmin 10
SYT10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYT10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-Wnt Niche Signaling Developmental | CHMP4C, DCAF12L1, DIRAS1, DPEP2, GIPC3, ITGA9, LUZP2, MSTN +8 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, AKAP12, CIT, COL27A1, ITGB4, LGI4, NRP2, SAMHD1 | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2 +2 more | View in SCUBA |
About the gene
| Chromosome | 12: 33374238-33439819 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Exocytosis |
Function
Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.