CSNK2B — Casein kinase 2 beta
CSNK2B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSNK2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, ERH +19 more | View in SCUBA |
| CD8⁺ T cells | Glycolysis Program Housekeeping | ADRM1, ENO1, MTHFD2, NUTF2, P4HB, PGAM1, PKM, POLR2E +6 more | View in SCUBA |
| Gamma-delta T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, NDUFA1 +12 more | |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CYB5R3, DHPS, ERGIC3 +13 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CYB5R3, DEGS1, DYNLRB1 +20 more | View in SCUBA |
About the gene
| Synonyms | Ckb1, Ckb2 |
|---|---|
| Chromosome | 6: 31665227-31670343 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Wnt signaling pathway |
Function
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling (By similarity). (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.