Mixed Housekeeping
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 15 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include AP2M1 (clathrin adaptor/endocytosis), KDELR1 (ER retention receptor), CHMP4A (ESCRT-III/multivesicular body), SKP1 (SCF ubiquitin ligase complex), STUB1 (CHIP E3 ubiquitin ligase), BAG1 (chaperone co-regulator), PRMT1 (arginine methyltransferase), DEGS1 (sphingolipid synthesis), JTB (Golgi/trafficking). All genes show weak membership and uniform expression across subsets, indicating a loosely co-regulated housekeeping module spanning vesicular trafficking, ubiquitin-proteasome, and general cellular maintenance. No specific biological program dominates; this is a mixed housekeeping module. Neighbor modules (M78, M6, M97) also capture UPS/housekeeping programs, consistent with a shared housekeeping network neighborhood.
Genes
AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1, DYNLRB1, H3-3A, JTB, KDELR1, MAF1, MLF2, NOL7, PDCD6, PRMT1, PRR13, PSMB4, SKP1, SNRPB, SSU72, STUB1, SUB1, SUPT4H1, TMX1, TSPAN3, UXT, WDR83OS
Most correlated modules
- Proteasome UPS · correlation 0.97
- Proteasome UPS · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.95
- Protein Homeostasis Mixed · correlation 0.95
- Protein Biogenesis · correlation 0.94
- ERAD Proteasome · correlation 0.94
- ER Protein Processing · correlation 0.93
- Low-Coherence Mixed · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.