CYB5R3 — Cytochrome b5 reductase 3

CYB5R3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CYB5R3's module in each cell type

Cell type	Module	Shares the module with
Endothelial	TGF-beta ECM Remodeling ECM remodeling	ADAM10, APLP2, CCNDBP1, DHRS3, EFEMP2, GNAS, HIPK2, MGST2 +10 more	View in SCUBA
Gamma-delta T cells	Interferon Stimulated Response Inflammation	AK3, AP2A1, CTNNBL1, DRG2, EPSTI1, EXOSC8, GPANK1, GUSB +6 more
Innate lymphoid cells	Cellular Metabolic Maintenance Metabolism	ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, DHPS, ERGIC3 +13 more	View in SCUBA
Lymphatic endothelial	Metabolic Housekeeping Housekeeping	CAPNS1, DMAC1, DUT, EID1, ESD, GNAI2, ISCU, OCIAD1 +5 more	View in SCUBA
Macrophages	Mixed Housekeeping Housekeeping	AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, DEGS1, DYNLRB1 +20 more	View in SCUBA
Smooth muscle cells	Ribonucleoprotein & translation RNA processing & translation	CRYAB, EEF1B2, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA, NCL +5 more	View in SCUBA

About the gene

Synonyms	DIA1
Chromosome	22: 42615730-42720870
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Molecular function	Oxidoreductase
Biological process	Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Function

Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.