DEGS1 — Delta 4-desaturase, sphingolipid 1
DEGS1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEGS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Endothelial Activation Inflammation | ANXA6, CNIH1, COTL1, DHRS7, F2R, FKBP10, FSTL1, JAK1 +8 more | View in SCUBA |
| Fibroblasts | Actin-Integrin Adhesion Migration & adhesion | ACTR2, ACTR3, C5orf24, CAP1, CD151, FERMT2, GNB1, ITGB1 +5 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Lymphatic endothelial | Proteasome Assembly Protein processing & ER | ARPC2, CSTB, GSTO1, MRPL14, PDCD5, POMP, PRELID1, PSMD7 +5 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DYNLRB1 +20 more | View in SCUBA |
| Smooth muscle cells | ER Secretory Trafficking Protein processing & ER | ARF4, GYPC, P4HB, PDIA6, SH3PXD2A, SSR3, TMED9, TMEM123 | View in SCUBA |
About the gene
| Synonyms | DEGS-1, Des-1, DES1, FADS7, MLD |
|---|---|
| Chromosome | 1: 224175756-224193441 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Isomerase, Oxidoreductase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.