B-cell Maturation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Module contains CD24, ITM2C, ZBTB20, PDCD4, SELENOM — markers associated with B-cell/plasma cell differentiation and naive/transitional states. CD24 is a transitional B-cell marker; ZBTB20 regulates plasma cell longevity; ITM2C is plasma-cell associated; PDCD4 is a differentiation/translation regulator. The collagen genes (COL4A3/4, TNR, CSGALNACT1) and ANK3 are unusual and may be peripheral, but the B-cell maturation markers dominate functionally. Strong coherence.
Genes
ANK3, ANTXR2, CD24, COL4A3, COL4A4, CSGALNACT1, ITM2C, PDCD4, PPP1R2C, SELENOM, TNR, ZBTB20
Most correlated modules
- Adhesion/Migration · correlation 0.74
- Activation/Migration · correlation 0.72
- Interferon Response · correlation 0.68
- MHC-I Antigen Presentation · correlation 0.68
- B cell activation · correlation 0.68
- IgA plasma cell · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.