CPLX1 — Complexin 1
CPLX1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CPLX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Angiogenic Receptor Signaling Developmental | ADGRG1, EPHB4, KDR, MGAT4A, PLXNA2, RASGRP3, ROBO4, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | CPX-I |
|---|---|
| Chromosome | 4: 784957-826129 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Exocytosis, Neurotransmitter transport, Transport |
Function
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.