RASGRP3 — RAS guanyl releasing protein 3
RASGRP3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASGRP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MIA2, MSI2, NR2C2 +18 more | View in SCUBA |
| Pericytes | Angiogenic Receptor Signaling Developmental | ADGRG1, CPLX1, EPHB4, KDR, MGAT4A, PLXNA2, ROBO4, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | CalDAG-GEFIII, GRP3, KIAA0846 |
|---|---|
| Chromosome | 2: 33436324-33564750 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) for Ras and Rap1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.