ROBO4 — Roundabout guidance receptor 4
ROBO4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ROBO4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1 +11 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, S1PR1 +6 more | View in SCUBA |
| Pericytes | Angiogenic Receptor Signaling Developmental | ADGRG1, CPLX1, EPHB4, KDR, MGAT4A, PLXNA2, RASGRP3, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | ECSM4, FLJ20798, MRB |
|---|---|
| Chromosome | 11: 124883691-124898500 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Receptor |
| Biological process | Angiogenesis, Differentiation |
Function
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.