PLXNA2 — Plexin A2
PLXNA2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLXNA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitophagy Stress Response Stress | C1QTNF12, CDA, CPNE2, FAM219A, FCN3, GSDMC, IGFBP3, INSR +7 more | View in SCUBA |
| Enterocytes | Long-gene transcript bias Technical artifact | CBLB, CSTPP1, GALNT6, GSDME, LARGE1, RAD51B | View in SCUBA |
| Pericytes | Angiogenic Receptor Signaling Developmental | ADGRG1, CPLX1, EPHB4, KDR, MGAT4A, RASGRP3, ROBO4, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ11751, FLJ30634, KIAA0463, OCT, PLXN2 |
|---|---|
| Chromosome | 1: 208022242-208244384 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.