DOK2 — Docking protein 2
DOK2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Autophagy Metabolic Stress Stress | CREM, CTSC, DNAJB6, EFHD2, GNG2, ICOS, MAP1LC3B, NDUFC1 +2 more | View in SCUBA |
| Gamma-delta T cells | Proteostasis/Chaperonin Protein processing & ER | BST2, CARD16, CBR1, CCT3, CCT6A, DYNLL1, HIKESHI, ME2 +13 more | |
| Monocytes | Mitochondrial Immune Regulation Mitochondrial & OxPhos | CALHM2, CORO1B, DNASE2, NDUFAF3, SIGLEC10, SLC39A1, UCP2 | View in SCUBA |
About the gene
| Synonyms | Dok-2, p56dok-2 |
|---|---|
| Chromosome | 8: 21908873-21913690 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Host-virus interaction |
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.