CREM — CAMP responsive element modulator

CREM belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CREM's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response BCR/AP1/NFKb pathway	CCNT1, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4, PER1 +7 more	View in SCUBA
CD4⁺ T cells	TCR signaling TCR/AP1/NFKb pathway	AP3M2, ATP1B3, CRYBG1, DCTN6, EZR, FAM177A1, FTH1, GCSAM +19 more	View in SCUBA
CD8⁺ T cells	Autophagy Metabolic Stress Stress	CTSC, DNAJB6, DOK2, EFHD2, GNG2, ICOS, MAP1LC3B, NDUFC1 +2 more	View in SCUBA
Endothelial	Endothelial NO Activation Endothelial cell development	BCL6B, BLOC1S1, CD99, CDH13, COX5A, DDAH2, DDX46, EEA1 +8 more	View in SCUBA
Fibroblasts	NFAT-cAMP Signaling Inflammatory	ACKR3, ADGRE2, ANKRD28, CHSY1, ELL2, FRMD4A, GPCPD1, RCAN1 +3 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1, IRF2BP2 +19 more
Innate lymphoid cells	NR4A Activation Response activation	ALG13, ARL4A, BCAS2, CASP3, CHMP1B, DDX24, DLL1, DNAJB9 +16 more	View in SCUBA
Macrophages	NF-κB AP-1 Signaling Inflammatory	ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more	View in SCUBA
Monocytes	Fc Receptor Activation Innate immunity	ARID5A, CD300E, FCGR2A, GLUL, LCP2, OLR1, PLSCR1, TRIM25	View in SCUBA
Mucosal-associated invariant T cell	cAMP Immune Regulation Immune regulation	FAM177A1, JMJD6, MAPKAPK2, METRNL, PDE4B, SNX9, SYAP1, USP36
Natural Killer cells	NK Activation Response activation	EIF1, FTH1, MAFF, NR4A2, SELENOK, SRGN, ZNF331	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ARL5B, ATG2A, ATP2B1, BTG1, DDIT4, FOSL2, GPR65, JOSD1 +4 more

About the gene

Synonyms	hCREM-2
Chromosome	10: 35126791-35212958
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Biological rhythms, Differentiation, Spermatogenesis, Transcription, Transcription regulation

Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.