GNG2 — G protein subunit gamma 2
GNG2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB activation/survival BCR/AP1/NFKb pathway | ARL4C, BCL2A1, CCR7, DDX21, ICAM1, IRF2BPL, LMNA, NAMPT +9 more | View in SCUBA |
| CD4⁺ T cells | Chemokine Migration migration & adhesion | CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GPBP1, KMT2E, PDE4B +7 more | View in SCUBA |
| CD8⁺ T cells | Autophagy Metabolic Stress Stress | CREM, CTSC, DNAJB6, DOK2, EFHD2, ICOS, MAP1LC3B, NDUFC1 +2 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GJA1, LEF1, MFGE8, PAPLN +5 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Natural Killer cells | NK Cell Maturation Differentiation | CAST, GZMB, HIPK2, PPP2R5C, PRKCH, STK10, SYNE2, ZEB2 | View in SCUBA |
About the gene
| Chromosome | 14: 51826195-51979342 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Transducer |
| Biological process | Host-virus interaction |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.