Proteostasis/Chaperonin
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 22 genes have a known function matching the annotation |
Why this annotation
HIKESHI is specifically required for nuclear import of HSP70 under heat stress, directly linking this module to the M118 heat shock neighborhood. CCT3 and CCT6A are TRiC/CCT chaperonin subunits also present in M118 (CCT4). BST2 (tetherin) is an interferon-stimulated gene suggesting some ISG overlap. PPID (cyclophilin D) and PRDX1 (peroxiredoxin) indicate mitochondrial/oxidative stress components. DYNLL1 participates in motor protein complexes. This module appears to represent a proteostasis/chaperone support program closely tied to the heat shock neighborhood, with a minor ISG component from BST2.
Genes
BST2, CARD16, CBR1, CCT3, CCT6A, DOK2, DYNLL1, HIKESHI, ME2, MOCS2, MRPS6, OAZ1, PCBD1, PPID, PRDX1, RNF181, SELENOW, SLC35B2, SNX3, TARS1, TSEN15, WBP2
Most correlated modules
- ER/Osmotic Stress · correlation 0.75
- Lysosomal Biogenesis · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.