EOGT — EGF domain specific O-linked N-acetylglucosamine transferase
EOGT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EOGT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CDC123, CNN2, DGKH, FADS3, FYN, MAP4K4 +7 more | View in SCUBA |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Smooth muscle cells | BAG3-HSPB8 proteostasis Stress | BAG3, C6orf62, CREBRF, DNAJB4, GOLGB1, HSPB8, IFRD1, PPP2R5E +5 more | View in SCUBA |
About the gene
| Synonyms | AER61, C3orf64, FLJ33770 |
|---|---|
| Chromosome | 3: 68975217-69013684 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.